Phagocytosis of Apoptotic Cells in Resolution of Inflammation. These results indicate that phagocytosis is a critical regulatory mechanism for neuronal damage and repair.
. The initial. It is performed by a series of cells we call professional phagocytes.
Here, we review efferocytosis-induced changes in macrophage metabolism that mediate the pro-resolving functions of macrophages. We compared the phagocytic uptake by macrophages of variants of L929sA murine fibrosarcoma cells induced to die by tumor necrosis factor-induced necrosis or by Fas. Fig.
. First, cell loss occurs during rigorous washing of adherent macro-phages required to ensure removal of noningested parti-cles.
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With regard to the cardiovascular system, an increased apoptosis rate occurs in advanced human atherosclerotic plaques.
Section snippets Plate-based assay for phagocytosis of apoptotic neutrophils. .
Macrophages clear apoptotic cells through a process called continual efferocytosis. Mar 1, 2008 · Removal of apoptotic cells by phagocytes plays an important role in many biological processes, including embryological development and tissue remodelling.
Mitochondrial apoptotic priming is a measure of how close to the apoptotic threshold a cell is.
Populations of phagocytic macrophages.
Like PAMPs, such. Some of these new observations challenge the way dying cells themselves are viewed, as well as how healthy cells interact with and respond to dying cells. 5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
Similarly, phagocytosis of apoptotic cells via TIM-4 requires β 1 integrins and activation of integrin-dependent signaling involving Src family kinases and FAK. Results: Phagocytosis of apoptotic cells was validated by use of inhibitors (cytochalasins) or low temperature and counterstaining with cell surface markers for the phago-cytic targets to exclude binding to the phagocytic surface. C. It is performed by a series of cells we call professional phagocytes. .
. Cold Spring Harb Perspect Biol.
apoptotic cells with the use of multiparameter ﬂow cyto-metric analysis.
5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
These results indicate that phagocytosis is a critical regulatory mechanism for neuronal damage and repair.
Signals on the surface of dying cells can direct specific phagocytic cell types (i.